FC Fernhill sealed the Premier Division title with five matches to go after crushing Finchampstead Athletic 5-0.
It was a sixth title in the last seven seasons for the defending champions, who have 12 wins and a draw from their campaign to date.
Second-placed Crowthorne Inn shared the spoils in a 3-3 draw at FC Meta, while Panthers moved up to eighth following a 4-1 home success against Golden Farmer Rangers.
AFC Crowthorne Stiffs are the new Division One leaders after they crushed Bracknell Athletic 7-0.
Joa Jardim and John Mulholland grabbed two goals apiece, with the others coming from Jason Ellary, Jamie Cooper and Mark Brown.
Loveman United drew 0-0 at Athletico Ascot and Berks County A overcame Woodley United 4-2.
Bearwood Wanderers remain top of Division Three, though they were held to a 0-0 home draw by fellow title contenders Bracknell Cavaliers.
Anton Hill got the only goal of the game as Bracknell Saint-Germain beat Silver Birch A 1-0, and Winnersh Town provided a most likely fatal blow to Braybrooke Athletic's title dreams, the second-placed side going down 7-2.
In Division Four, FC Harmanswater overcame Bracknell Athletic Reserves 2-0, Silver Birch thumped Bracknell Titans 4-0 and Bracknell Cavaliers Reserves won 2-0 at AFC Crowthorne Old Boys.
Woodley Saints reached the final of the Junior Cup with a 5-0 demolition of Silver Birch Dynamos, and Bracknell Corinthians are into the last eight of the Subsidiary Cup following a dramatic 5-4 penalty shoot-out success at Ashridge Park Royals.
The two sides had earlier drawn 1-1.
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